Sensitizing enhancement ratio of combination group was 1.5 in growth and 1.7 in regrowth. Tumor regrowth delay time in combination therapy and irradiation alone groups was 23.4 and 10.2 days. Results: For A549 xenografts in radiation alone, gefitinib alone and combination therapy groups, the percentage of tumor growth inhibition was 22.7%, 12.4% and 38.2%, respectively (F=25.75, P=0.000). Percentage of tumor growth inhibition, growth delay time and regrowth delay time were evaluated. Tumor diameter was measured every other day. In the combination group, radiotherapy was performed 2 hours after Gefitinib administration. Gefitinib was daily administered by gavage at 100 mg/(kg Radiation schedule was 3 fractions of 5 Gy, once daily. The mice were derided into 4 groups: control, irradiation alone, Gefinitib alone and radiation combined with Genifitib. Methods: Human lung adenocarcinoma cell line A549 was used to establish nude mouse xenograft tumor model. Objective: To investigate the effect of Gefitinib on radiosensitivity of human lung adenocarcinoma xenograft in nude mouse. Wang Hui Li Tianran Tian Jiahe Qu Baolin Zhu Hui International Nuclear Information System (INIS) The effect of .Īnti-EGFR therapy radiosensitizes human lung adenocarcinoma xenograft in nude mouse Xenogen in vivo imaging system was used to monitor tumor growth and metastasis. Methods: Withaferin A was injected through a portal vein to the orthotopic liver tumor in a nude mice model. Purpose: To investigate the effect of withaferin A on tumor growth and metastasis in liver in a nude mouse model.
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